Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications.Yet, robust delivery to extrahepatic tissues remains a challenge.Conjugating lipids (e.g., docosanoic acid [DCA]) to siRNA supports extrahepatic delivery, but tissue accumulation remains lower than that achieved in liver by approved siRNA therapeutics.
An unusual presentation of peripheral buttressing bone in anterior maxilla: Case report and management
The phenomenon of buttressing bone formation is relatively uncommon in the alveolar bone, more so in the anterior maxilla.In our case, peripheral buttressing bone formation presented as an isolated 406 hard gingival swelling with relation to 21 in a 14-year-old girl.Radiographic presentation was normal with no evidence of bone loss or altered bone